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The bioavailability advantage of injectable glutathione translates to more predictable therapeutic responses, higher peak plasma concentrations, more efficient cellular uptake, and reduced dosing requirements compared to oral forms

There is a genetic predisposition leading to deficiency in production of the important antioxidant powerhouses in the body

The mechanism and result are similar to that of GSTP and JNK, in that GSTM1 sequesters ASK1 through complex formation and prevents its induction of the pro-apoptotic p38 and JNK portions of the MAPK signaling cascade

the dosage was then raised to 2,000 mg/day, administered orally, until the end of the study (355 days)