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DISCUSSION GLP-1 analogs and DPPIV inhibitors are now one of the main drugs used for treatment in patients with diabetes mellitus

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Conclusion In conclusion, the emerging observation that some complications of diabetes are associated with an hyperactivation of RAAS has provided the pathophysiological basis to study the effects of GLP1-RA and SGLT2-i on RAAS to better explain the cardio-reno-protective effect demonstrated by the clinical trials, beyond their role on glucose control