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CHRONIC INTOXICATION Chronic intoxication occurs when low levels are consumed for long periods of time , representing a greater risk due to its higher prevalence and the great economic impact on companies
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For instance, tumor-associated macrophages (TAMs) exert a dominant inhibitory effect by significantly upregulating the expression of coinhibitory ligands such as PD-L1, thereby reducing the proportion of activated CD8 + T cells, suppressing their proliferation, and potentially inducing clonal anergy or deletion [113, 114]
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