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Insulin sensitivity There were no differences in delta change of HOMA-IR at week nine (0.6 0.3, n = 18 vs 0.4 0.3, n = 17, p = 0.65) and week 18 (0.7 0.3, n = 18 vs 0.2 0.4, n = 17, p = 0.23) or Matsuda Index at week nine (0.5 0.5, n = 17 vs 0.01 0.2, n = 17, p = 0.56) or week 18 (0.4 0.7 n = 17, vs 0.1 0.3, n = 17, p = 0.75) between the inulin and cellulose groups after adjusting for weight lost
For example, combined GLP-1 and GIP receptor deficiency is necessary to fully eliminate the glucose-lowering action of DPP-IV inhibition in mice 15 , -cell responsiveness to both GLP-1 736 and GIP is increased in T2D patients with improved glycemic control 16 , and DPP-IV inhibition can partially restore the insulinotropic effect of GIP in T2D patients 17
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As above, full details and formulas appear in Addition File 1
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