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PHYSIOLOGICAL RESEARCH, Volume 73, pages 515-527
In the STEP UP clinical trial, the 7.2 mg dose produced a mean weight loss of 20.7% at 72 weeks, compared with 17.5% at the previously approved 2.4 mg dose and 2.4% with placebo
Moreover, shifts in the cellular glutathione redox state may reversibly modify redox-sensitive thiol groups in target proteins, either through glutathionylation or formation of cysteine cross bridges
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