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This causes a self-perpetuating cycle of damage.* The cell maintains efficiency through a natural response called mitophagy

One small placebo-controlled, double-blind, crossover trial looking to measure the impact of glutathione on sperm had patients administer 600mg of glutathione intramuscularly every other day for two months

Jedrychowski W: Biological meaning of the prospective epidemiological study on chronic obstructive lung disease and aging

This suggests that the oxidative and inflammatory stress that appears to play a fundamental role in the aging of both the immune system and the nervous system, can be counteracted to certain degree by administration of antioxidants, and that antioxidant diet supplementation may be useful to neutralize or retard age-related homeostatic impairment (Figure 2)