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Endocrinology 159 (9), 33403350 (2018)
J.WalikonisR
How It Is Studied Pharmacological characterization of sema at the GLP-1 receptor uses cAMP accumulation assays in GLP-1R-expressing HEK293 cells, radioligand competition binding with [125I]-GLP-1 or [3H]-exendin-4, and beta-arrestin recruitment BRET assays to determine binding affinity, efficacy, and biased agonism profiles
Overall, the elimination half-life is approximately 13 hours , making it a suitable formulation for once-daily injection
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