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Except for patients with Hunner lesions (see Statement 19), initial treatment should be nonsurgical

First, if the solution has become contaminated with bacteria due to improper storage of a multi-dose vial, injection carries a risk of infection

Furthermore, some NGPs release extracellular vesicles and other bioactive metabolites that communicate with immune, epithelial, hepatic, and neural tissues, suggesting that their benefits may arise as much from postbiotic signaling as from mere colonization or competitive exclusion (539)