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Differences observed between earlier and later periods in the medication-specific cohorts are likely due to more recent available evidence regarding the efficacy and effectiveness of these therapies, evolution of guideline recommendations, and indication spaceparticularly for SGLT2ioccurring in 20202022

KPV suppresses pro-inflammatory cytokines at the mucosal and systemic level

This is not a side effect of tirzepatide in the pharmacological sense

Mechanistically, tirzepatide treatment led to activation of brain areas that are known to control appetite and feeding behavior in rodents [67], a finding that is consistent with another GLP-1 analogs (semaglutide) activity in the brain [68]