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The new drugs, which were originally developed to treat diabetes, are targeting the biology that makes weight so hard to lose and keep off: They dial down hunger in the brain, slow gastric emptying, and improve post-meal insulin signaling
In other settings (like surgical cohorts), it may appear more often simply because more tissue is being sampled and examined carefully
This adverse effect may negate any benefit on renal function that might be achieved through GLP-1 receptor signaling [91, 92]
Marketing claims are not required to be scientifically validated before being placed on the label
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