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Pathological examination showed an increased number of follicles with cystic dilation in the DHEA-treated rats, whereas the control group displayed a normal ovarian morphology ( Figure 1C )

Yang M et al

Supporting Profile (80/100) : The formula includes 1,500mg of creatine monohydrate, 1,250mg of betaine anhydrous, 1,600mg of beta-alanine, 190mg of caffeine, and L-theanine, all disclosed

Potential Mechanism(s) 289-291 : Disrupting normal cellular function, triggering inflammation, and accelerating aging Raising brain oxidative stress levels, impairing mitochondrial function, increasing toxic protein accumulation, and suppressing production of BDNF, a protein that stimulates neuronal growth and connectivity, inhibiting neuroplasticity Scientific Evidence: Study 1 Study Design: RCT (Negative) Subjects: 75 elderly participants with type 2 diabetes Results: Lowering dietary AGE intake did not enhance the pro-cognitive effects of a blood glucose-lowering diet after six months 292 Study 2 Study Design: Observational/Correlational Subjects: 684 older adults without dementia Results: Dietary AGE intake (estimated using diet records) was associated with faster cognitive decline during an average of three years of monitoring 293 Study 3 Study Design: Observational/Correlational Subjects: 4,041 Japanese subjects aged 60 years and older Results: Higher AGE levels in skin were associated with lower scores on tests of cognitive performance 294 Study 4 Study Design: Observational/Correlational Subjects: 3,389 adults in the Netherlands Results: Among 2,890 participants without dementia at the beginning of the study, those with higher skin AGE levels were more likely to develop dementia during a maximum of 18.7 years of monitoring