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Its triple-agonist mechanism targeting GLP-1, GIP, and glucagon simultaneously is genuinely novel, and the liver fat reduction data (82% at 24 weeks, per Sanyal et al., Nature Medicine 2024) is in a class of its own

Some strength can follow lean-mass loss if you don't train, but resistance exercise during weight loss preserves both muscle and strength far better than dieting alone

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While metformin indirectly promotes weight loss by activating GLP-1R, the pathways the GLP-1RA utilize have a more immediate effect in reducing gastric emptying and heightening levels of satiety [8]