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Preclinical studies have shown that liraglutide and semaglutide protect skeletal muscles from obesity-induced muscle atrophy via the sirtuin 1 (SIRT1) pathway in muscle tissue and myotubes of C2C12 cells and are associated with improvement of impaired glucose tolerance and IR [16]
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And the mild diuretic effect that sometimes accompanies significant weight loss further depletes sodium, potassium, and magnesium stores
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