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Over the following decades, studies looked at its role in collagen and elastin support, wound healing, antioxidant activity, inflammatory signaling, and the production of glycosaminoglycans that help keep skin hydrated and firm

[1] The formulation delivers 17-estradiol in a depot that slowly releases hormone over several weeks, thereby potentially supporting more stable serum estrogen concentrations than daily oral or transdermal preparations and potentially improving symptom control for individuals with hypoestrogenism or menopausal vasomotor instability

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Bibliografia Schoenenberger GA, Monnier M (1977)