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Most of these effects appeared during the dose escalation phase and resolved within the first 12 weeks

Vitamin B 12 improves transcriptional fidelity during reprogramming To address the role of H3K36me3 during reprogramming, we performed (i) chromatin immunoprecipitation followed by sequencing (ChIPseq) for H3K36me3 and (ii) bulk RNA-seq in MEFs undergoing reprogramming, with and without supplementation of vitamin B 12