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ABMR samples showed significant upregulation of OXPHOS, pentose phosphate pathway, riboflavin metabolism, N-Glycan biosynthesis, glycolysis/gluconeogenesis, citrate cycle (TCA cycle), pyrimidine metabolism, fructose and mannose metabolism, glycosaminoglycan degradation, and other glycan degradation

( Lancet 2023, NCT04982575 [12] ) randomised 92 adults with type 2 diabetes on metformin, with or without an SGLT2 inhibitor, 1:1:1 to CagriSema (n=31), semaglutide (n=31), or cagrilintide (n=30), all escalated to 2.4 mg, across 17 US sites over 32 weeks

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Inflammation further decreases nutrient utilization