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A Mercer 2026 strategy survey found 77% of large employers rated managing GLP-1 costs as "extremely or very important" ( [25] )

Retatrutide is a synthetic peptide drug designed to mimic and activate three natural hormone receptors: GLP-1, GIP, and glucagon

At the same time, investigators and clinicians observing outcomes in controlled and real-world research contexts have noted something more subtle and complex: changes in motivation, pleasure, and reward processing , sometimes described as emotional flattening or anhedonia in certain test subjects

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