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Medical Considerations: Semaglutide or Tirzepatide, including micro-dose programs, cannot be prescribed and should not be purchased by individuals with a BMI under 25 (or under 20 for micro-dosing), an eating disorder, diabetes, gallbladder disease, history of drug or alcohol abuse, recent bariatric surgery, pancreatitis, medullary thyroid cancer or a family history of it, diabetic retinopathy, multiple endocrine neoplasia type 2, or those who are pregnant, breastfeeding, or planning to become pregnant
This work was supported by a grant from the Ministry of Education, Culture, Sports, Science, and Technology, Japan (20590808, T Ito) and the Research Committee provided by the Ministry of Health, Labour, and Welfare Japan (50253448, T Ito)
N Engl J Med 377(1):1327 Wilding JPH et al (2021) Once-weekly semaglutide in adults with overweight or obesity
2012;129(3):e827-e841
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