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hypoglycemia risk if on insulin) eGFR below 30 (tirzepatide exclusion in SURMOUNT-5) Recent cardiac event or NYHA Class IV heart failure Active suicidal ideation (trials excluded PHQ-9 scores of 15 or above) If your tirzepatide vs semaglutide question is pure weight loss without comorbidities, tirzepatide wins on the numbers

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Being aware of these side effects and working closely with your healthcare provider can help ensure that your treatment is safe and effective

A significant overdose (double dose or more) warrants immediate medical attention