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GST-HDAC1 pull-down Approximately 1 g of GST or GST-HDAC1 protein bound to Glutathione Sepharose 4B beads was incubated with 1 g of purified His-C16orf87 protein in binding buffer (50 mM TrisHCl, pH 7.5, 100 mM NaCl, 10% glycerol, 0.5% NP-40, and 10 mM MgCl)

The maker of Wegovy and Ozempic, Novo Nordisk, has predicted a sharp drop in revenues this year owing to what its boss described as a painful push by Donald Trump to lower US weight-loss drug prices, rising competition, and the loss of important patent protections

Meet the BMI threshold and engage with the program