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To begin with, GLP-1 is secreted by L cells in the lower intestine, and its secretory stimuli include nutrients, the gut microbiota itself, and metabolites of the gut microbiota, such as short-chain fatty acids 47,48
It progresses through four stages: Liver disease may not show signs in the beginning phases
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20 Note: Intranasal dosing is typically between 300-600mg/daily in divided doses, often 100-200mg three times daily
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