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Overall, preclinical studies have shown that NAD + and mitochondrial metabolism play a crucial and intertwined role in aging and age-associated diseases, as well as being possible therapeutic targets for ameliorating these conditions
This makes it relevant for forehead lines, crow feet, and other expression-related wrinkles
Isolated cells were characterized as fibroblasts by morphological appearance and expression pattern of specific proteins as described previously [24, 25]
Ramos-Lev AM, Marazuela M
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