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H2 metabolism is widespread and diverse among human colonic microbes
A major regulator of the rate of NADPH production by the PPP in response to oxidative stress is the allosteric activation of G6PDH
The newer, longer-acting versions like Ozempic and Wegovy were approved more recently (Ozempic in 2017, Wegovy in 2021), but theyve been studied in large clinical trials involving thousands of patients over several years
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