As tau becomes hyperphosphorylated, its capacity to support microtubule assembly and stability diminishes, resulting in increased levels of unbound tau that may aggregate into tangles (if not secreted or degraded in the lysosome) [107]
Disclaimer: These timelines are based on average clinical observations
doi: 10.3389/fnut.2026.1822840 Received 04 March 2026 Revised 27 April 2026 Accepted 29 April 2026 Published 20 May 2026 Corrected 28 May 2026 Volume 13 - 2026 Edited by Camelia Munteanu, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, Romania Reviewed by Yasutaka Shigemura, Tokyo Kasei University, Japan Cornelia Witthft, Linnaeus University, Sweden Updates Copyright 2026 Haarhuis, Ahn-Jarvis, Savva, Day-Walsh, Ferns, Hughes, Triller, Al-Jaibaji, Philo, Acaroz, Perez-Moral and Kroon
(ODS 2023, NatMed 2025) For supplementation or pharmacological purposes, LC is available in capsule, tablet or powder form for oral use and as a solution for intravenous administration