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While these primary mechanisms don't necessarily cause fatigue directly, the downstream effectsparticularly reduced caloric intake and gastrointestinal symptomsmay contribute to feelings of tiredness in some individuals

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Study Design and Participant Selection This exploratory secondary analysis was conducted within a randomized, placebo-controlled clinical trial involving adults aged 18 to 65 years with obesity, defined as a body mass index between 32 and 43 kg per square meter, and without diabetes mellitus

"Prunes are a source of fiber, sorbitol and polyphenols, which promote regularity and support a healthy gut microbiome," Manaker says