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The co-crystal structure of Compound 71 bound to PDE10A revealed that, in addition to existing interactions, an extra halogen bond formed between the chlorine atom of Compound 71 and Y524, contributing to enhanced inhibitory activity (Figure 18B)
doi: 10.1155/2018/1919482 172
When reconstituted with bacteriostatic water and stored consistently in a refrigerator (2-8C), the solution should remain stable and potent for at least 30-45 days
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