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Cumulus cells play critical roles in the maturation of the nucleus and cytoplasm in the oocyte, as they allow the interchange of molecules with the oocytes 74
They rarely describe failure states: persistent cloudiness from aggregated peptide, gel-like consistency from incomplete dissolution of a large pellet, or a precipitate forming hours after initial clarity due to slow aggregation
This proline-rich sequence introduces conformational rigidity that strongly resists proteolytic degradation by trypsin, chymotrypsin, and catheptic proteases
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