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The hallmark signs of B12 deficiency are neurological issues, including numbness, tingling, or pins and needles in hands and feet

Wei et al., 2025

J Pediatr Gastroenterol Nutr 50:132139 Varga C, Laszlo F, Fritz P, Cavicchi M, Lamarque D, Horvath K, Posa A, Berko A, Whittle BJ (2007) Modulation by heme and zinc protoporphyrin of colonic heme oxygenase-1 and experimental inflammatory bowel disease in the rat