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Given that GCL or GGT pharmacological inhibition or silencing effectively blocks the growth of lymphoid tumor cells in 3D gels, including TIC-like cells, we propose that high glutathione levels in the minority of tumor cells that thrive in 3D gels counteract ROS-induced cell death

Maintenance of healthy structure and function of the lens depends on proper functioning of complex cellular machinery, which if compromised, can lead to decreased lens transparency (Mathias 2010

The other NAD forms showed only modest increases in response to niacin, suggesting differential regulation of individual metabolite pools in steady state

Homogenates were centrifuged at 800 g for 10 min at 4 C, and the supernatant was sonicated on ice for 20 s before protein quantification (BCA protein assay, Pierce, Rockford, IL, USA)