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doi: 10.1016/0092-8674(90)90661-w 41 FarrokhiEGhatrehSamaniKHashemzadeh ChaleshtoriMTabatabaiefarMA

Record clinical rationale and dosing in structured EHR fields, restrict access to care-team members, and transmit orders via secure e-prescribing channels

How injectable/oral GLP-1 medications work: Mimic the GLP-1 hormone with engineered modifications for extended duration Bind to GLP-1 receptors to enhance insulin release and reduce glucagon Slow gastric emptying by 20-50%, promoting satiety Supported by large randomized controlled trialsthe STEP trials showed 14.9% mean weight loss at 68 weeks versus 2.4% for placebo The short answer on why patches cant deliver these drugs: GLP-1 molecules are relatively large peptide chains (molecular weight 3-5 kDa) that cannot effectively penetrate the skin barrier through passive transdermal diffusion

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