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It must be administered via injection (intramuscular or intravenous) to maintain its biological activity

The epidemiology of depression across cultures

The risk increases if these agents are used alongside insulin or sulphonylureas

Major drug Interactions: Decongestants Local anesthetics w/ sympathomimetics Antihypertensives CNS depressants Drugs metabolized by P450-2D6 Concomitant use of MAOI's can cause potentially fatal hyperpyretic crisis & seizures History: The therapeutic & commercial success of phenothiazine antipsychotics initiated a large scale search for more effective antipsychotics during the early 1950's