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Although the therapeutic benefits of GLP-1 RAs have been extensively studied in diabetic CKD, their application in AS requires further exploration

doi: 10.2337/cd22-0060

If the primary outcome showed superiority, secondary outcomes were tested in a pre-specified order to control the type I errors Total eGFR slope (the annual rate of change in eGFR from randomization to the end of the trial) Major cardiovascular events (a composite of nonfatal MI, nonfatal stroke, or death from CV causes) Death from any cause The other supportive secondary outcomes are shown in the figure below

Common adverse effectsnausea, vomiting, diarrheatypically diminish with gradual dose titration